2025 · Week 16 · 2025-12-23
San Francisco 49ers win.
| SF | IND | |
|---|---|---|
| Final score | 48 | 27 |
| Total yards | 440 | 312 |
| Passing yards | 295 | 254 |
| Rushing yards | 145 | 58 |
| First downs | 28 | 19 |
| 3rd down | 7-11 | 5-10 |
| 4th down | 1-1 | 0-1 |
| Total plays | 66 | 58 |
| Yards / play | 6.7 | 5.4 |
| Comp / att | 25/34 | 23/36 |
| Yards / pass | 8.4 | 6.7 |
| Rush attempts | 31 | 20 |
| Yards / rush | 4.7 | 2.9 |
| Red zone (made-att) | 4-6 | 2-2 |
| Turnovers | 1 | 2 |
| Interceptions | 1 | 1 |
| Fumbles lost | 0 | 1 |
| Sacks-yds | 1-0 | 2-23 |
| Penalties-yds | 2-36 | 6-45 |
| Drives | 10 | 10 |
| Possession | 33:05 | 26:55 |
